An Integrative Circulatory System Model Using Foreground-Background Multi-Time Scale Simulation Environment

An integrative physiological model of the human circulatory system coupled with numerous subsystems is presented. The development of a human simulator to allow real-time interpretation of sensor data from home health monitoring devices and other biomedical sensors can be achieved using an integrated two model environment. This approach combines a foreground continuous time circulatory system model with a background discrete time global physiological model. This foreground-background architecture is based on the temporal and spatial requirements of the simulator and the various physiological subsystems. It allows the simulation to retain the complex interactions of the various physiological systems in order to prevent subsystem isolation and still perform real-time data analysis and interpretation. Innovative solutions need to be developed to optimize bidirectional parameter interface between the two model environments. A detailed description of the foreground cardiovascular model is presented along with initial simulation results. MIT d’Arbeloff Laboratory for Information Systems and Technology